Himalaya Liv52 / LiverCare
Benefits of Liv52:Liver Care, Detoxification, Treats Cirrhosis, Hepatitis
World's #1 Liver Support Formula 
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Liv-52® also known as LiverCare® is a herbal formulation that is effectively the World's #1 Liver Support Formula. Liv52 has been validated by the 276 clinical trials and research studies. Liv.52 restores the useful efficiency of the liver, prevents the loss of functional integrity of the cell membrane, maintains the cytochrome P-450, hastens the recovery period and ensures early restoration of hepatic functions in infective hepatitis.In pre-cirrhotic conditions, Liv.52 arrests the total progress of the disease and prevents further liver damage. As a every day health supplement, Liv.52 improves the appetite and the digestion and assimilation processes.
Liv.52 facilitates rapid elimination of the acetaldehyde, the toxic intermediate metabolite of alcohol metabolism, and ensures the protection from alcohol-induced hepatic damage. Liv.52 moderate the lipotropic activity in chronic alcoholism, and prevents fatty infiltration of the liver.
Benefits of Liv52
- Improves the functional effectiveness of the liver
- Detoxification and protection from the harmful food and medication toxins
- Very beneficial in the cirrhotic and pre-cirrhotic cases
- Regulates levels of liver enzymes
LiverCare Liv52 tablets can help in the prevention and treatment of:
- Viral hepatitis
- Alcoholic liver disease
- Pre-cirrhotic conditions and early cirrhosis
- Protein energy malnutrition
- Loss of appetite
- Radiation and chemotherapy-induced liver damage
- As an adjuvant with the hepatotoxic drugs
- A valuable adjuvant by during convalescence and prolonged illness
Liv52 / LiverCare Ingredients (Per Tablet):
- Capers / Himsra (Capparis spinosa) 65mg
- Wild chicory / Kasani (Cichorium intybus) 65mg
- Ferric Oxide Calx / Mandur Bhasma 33mg
- Black Nightshade / Kakamachi (Solanum nigrum) 32mg
- Arjuna (Terminalia arjuna) 32mg
- Negro coffee / Kasamarda (Cassia occidentalis) 16mg
- Yarrow / Biranjasipha (Achillea millefolium) 16mg
- Tamarisk / Jhavuka (Tamarix gallica ) 16mg
processed in Bhringaraja,Bhumyaamlaki, Punarnava, Guduchi, Daruhardra, Mulaka, Amalaki, Chitraka,Vidanga,Haritaki & Parpata.
Preservatives: Methylparaben, Propylparaben, Methylparaben Sodium, Propylparaben Sodium.
Liv52 Packaging
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The Liv.52 plastic container the stands at 6.5cms x 4.5 cm's and consists of 100 tablets. The bottle is foil sealed for your protection - confidence that there has been no tampering; and each tablet has an "H" imprinted on it - standing for Himalaya. The container has a 3 year shelf life so buy in bulk and save. The tablets have a real sweet, red coating on them and are not bitter or foul tasting at all. The tablets themselves are small at about 0.5 cm's so are very easy to consume. |
Directions for taking Liv52
2 - 3 tablets twice each day with meals or as prescribed by your physician
Liv52 / Livercare from Himalaya Herbals
Liv52 / LiverCare is from the renowned Himalaya Herbals brand that endorsed by over 250,000 doctors worldwide and used by customers in over 60 countries. Liv-52 was introduced in 1955 by Himalaya Herbal Healthcare. Since then, it has been sold into worldwide and is recognized by thousands of health professionals as one of the most successful liver formulas, with great beneficial effects reported in over 300 studies.
Himalaya's Liv-52 has been widely approved as an herbal drug for liver in Switzerland by its FDA equivalent. It is believed to be the first multi-herb remedy that granted regulatory approval as a drug, which is an outstanding feat for an herbal product.
Himalaya Herbals products have been researched clinically and standardized to get guarantee bioequivalence. Bioequivalence refers to get ensuring that the product on the market is equivalent to the one on which clinical trials were effectively conducted. Himalaya Herbal Healthcare uses the chromatographic fingerprinting, one of the most sophisticated standardization techniques, to get ensure consistent quality and performance
Liv52 News
· According to figures available for July 2007, Liv.52 has achieved the highest sales by value and the top selling drug in India beating other chemical based allopathic medicines. Liv.52 had sales that exceeded Corex, Phensedyl and Novartis which are best selling medicines of pharmaceutical those companies like Pfizer.
· Himalaya's Liv-52 has been approved as an herbal drug for liver in Switzerland by its FDA corresponding. It is believed to be the first multi-herb remedy decided regulatory approval as a drug, which is an outstanding feat for an herbal product.
Information on Liv52 obtained from:
What is liver damage and how can Liv.52 treat liver disease?
Liver damage can be caused by alcohol, viral hepatitis, medications specially those containing acetaminophen (tylenol), statins and niacin as well as toxins from the food and the environment. The liver is a unique organ in that it can reinforce itself. However when the damage is ruthless, scar tissue is formed causing cirrhosis at which point, the liver is unable to function proficiently. Liver damage can also be caused by the accumulation of fat in liver known as steosis. While 50% of patients with other liver disease may show no symptoms at all, some of the symptoms of other liver disease are fatigue, jaundice, dark urine, itching, low appetite, light colored stools, fluid retention in the stomach.
Liv.52 is a most powerful detoxifier. Liv.52 helps to flush out toxins from the alcohol consumption as well as drugs and food. By removing the damaging agent , Liv.52 allows the liver to substitute damaged tissue and regenerate itself. Liv.52 aids in the effective metabolism of drugs by maintaining levels of CYP or Cytochrome P450. Hepatic cytochromes P450 play an important role in the metabolism of drugs and toxins in the liver. Liv.52 also improves the much appetite (appetite suppression is another effect of hepatitis and liver damage) as it basically causes food to get absorbed and assimilated more proficiently. It also helps to regulate the liver enzymes. Liv.52 also prevents fat from the infiltrating the liver.
What are the ingredients in Liv.52 and how do they help the liver?
The herbs used in Liv.52 have been documented into various ancient and modern medical literature for their liver beneficial properties.
Capers (Capparis Spinosa) are known to improve the liver functions. These are hepatic stimulants and also protect the liver. Capers also have large amounts of rutin which is basically an anti-oxidant and bioflavonoid which aids in the absorption process and inhibits inflammation.
Wild Chicory (Cichorium intybus) has been referenced in ancient Greek writings of Horace, Virgil and Pliny. It was called "Friend of the Liver" by Galenus due to its interesting effect on the liver. chicory is known to promote the bile production, remove excessive internal mucus and release gallstones. It is widely used in herbal and homeopathic preparations for jaundice, liver and gall bladder problems.
Black Nightshade (Solanum nigrum) is known for its hepato-protective effects in cases of the toxicity caused by medicines. The juice is used as remedy for enlarged liver and spleen and is considered well effective in liver cirrhosis. It is also used for skin disorders as well as to cure other ear and eye disease
Arjuna (Terminalia arjuna) The Arjuna bark helps to shelter DNA against toxins. It is mainly a cardiac protective and also has a general tonic effect in liver cirrhosis. Arjuna helps diminish cholesterol. Research has shown Arjuna to have an anti-oxidant effect on provoke liver cancer in rats. There was also a significant (P<0.05) increase in superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase glutathione reductase and glucose-6-phosphate dehydrogenase, reduced glutathione, vitamin A, vitamin C, vitamin E, total sulfhydryl groups (TSH) and non protein sulfhydryl groups (NPSH) in liver and kidney of alloxan persuade diabetic rats.
Negro coffee (Cassia occidentalis) Negro Coffee aids in detoxification of the liver. It is a hepatoprotective, purgative, laxative and admirable diuretic. It regularizes the bowel movements and eliminates internal bacteria.
Yarrow (Achillea millefolium) Yarrow has usually been used to stop blood loss and finds mention in ancient literature when Achilles used it to stop the bleeding on his soldiers. However it has also been used to treat the liver disease. It helps treat in loss of appetite, gallbladder conditions, urinary infections and peptic ulcers. It also relieves the inflammation of internal organs.
Tamarisk (Tamarix gallica ) Tamarisk is used in cases of hepatic insufficiency. It is also used to stop the blood loss in bleeding disorders.
What are the liver conditions that Liv.52 can treat?
Liv.52 helps to care for the liver damage caused by alcohol abuse, chemotherapy, radiation as well as medicines that are damaging to the liver, hepatitis that caused by the viral infections, cirrhosis of the liver, weight loss and lack of appetite. Liv.52 is also functional as a general health tonic and into recovery after illness as it aids in capable functioning and detoxification of the liver.
Who can benefit from taking Liv.52?
Liv.52 is beneficial for people who drink alcohol as it helps to maintain liver health and heal any damage. Liv.52 is also functional for people who are on medications or convalescents. It helps in intocreasing metabolism and the appetite. Liv 52 can also be taken as a common health supplement by all because it detoxifies, promotes strength and helps in maintaining the good health. Liv52 is a good class stimulator of appetite, haemopoiesis and a pronounced anabolic agent.
Liv.52 Research and Clinical Studies
Liver disorders during pregnancy and their management
The Antiseptic 2008; 105 (4): 193-196
Arun Kumar Mitra, MBBS, DGO, MO, FICOG, FRCOG PhD (London) Former Professor and Head, Department of Obstetrics and Gynecology, Medical College. Calcutta.
Pralhad S. Patki*, M.D., Head - Medical Services and Clinical Trials
S.K. Mitra, M.D., Executive Director
R&D Center, The Himalaya Drug Company, Bangalore, India. (*Corresponding Author)
Various liver diseases can occur throughout pregnancy making a normal pregnancy a high-risk pregnancy. These liver diseases include Viral Hepatitis, Hepatitis A virus infection, Hepatitis B virus infection (HBV), Hepatitis C infection, Hepatitis delta virus infection (HDV), Acute Fatty Liver of Pregnancy (AFLP), Autoimmune Hepatitis (AIH), Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis, Gallstone Disease in Pregnancy, Drug induced hepatitis
The study involved the 84 patients. 9 pregnant women had severe viral hepatitis. 21 of eighty four patients had undergone liver biopsy, Histopathological examinations of these patients of viral hepatitis had therefore indicated extensive periportal round cell infiltration, fibrosis and scaring. Liv 52 was given to the patients and all except one of these patients recovered completely after 6 weeks of treatment. Further, Liv.52 did not produce any unpleasant effects in any of the 84 patients who underwent Liv.52 drug therapy. In spite of tremendous strides in modern medicines, few drugs are those known to protect the liver from damage. Liv 52 showed a immense promise in this situation as a safe and effective medication.
Meta-analysis of 50 Phase III clinical trials in evaluation of efficacy and safety of Liv.52 in infective hepatitis
Kolhapure, S.A., M.D., Senior Medical Advisor, and Mitra, S.K., M.D., Executive Director,Research and Technical Service, R&D Center, The Himalaya Drug Company, Bangalore, India
ABSTRACT Hepatitis A (HA) has a worldwide distribution by occurring in epidemic and sporadic patterns. Hepatitis A is an acute, but benign form of the viral hepatitis and near the beginning renormalizations of hepatic functions with symptomatic and clinical recovery are the objectives into the clinical management of HA. meta-analysis is the term it used to describe quantitative methods for merge information across different studies and this study was planned for meta-analysis of the efficacy and also much safety of Liv.52 tablet and syrup, in HA, as reported in 50 published study reports.
All study reports that appraise efficacy and safety of Liv.52, were actually included for the meta-analysis, regardless of the study design, but Phase I and II clinical, experimental and preclinical studies were those excluded from the meta-analysis. Each study was so abstracted for the number and ages of enrolled patients, and changes in the biochemical parameters [serum bilirubin (SB), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphatase (SAP), serum albumin (SA) and serum globulin (SG), and prothrombin time (PT)] from baseline to values all at the end of study and total duration of clinical recovery were recorded. Incidence of unpleasant events during the study period and patient compliance to get the drug treatment was noted. The predefined prime endpoints were to determine level of statistical consequence for symptomatic improvement, renormalization of biochemical parameters and total duration of the clinical recovery. The predefined secondary endpoints were also numbers of adverse events during the study period and compliance to the drug treatment.
Total 50 clinical studies that conducted over a span of 30 years were considered for this meta-analysis and the mean duration of these studies was 6.62 months. Out of total fifty studies, 3 were double-blind placebo-controlled studies, 21 were placebo-controlled studies, 22 were non-comparative studies and 4 studies were case reports. Total 4490 patients were in fact enrolled in these studies and 233 children were part of study population. Cumulative data analysis here showed a significant reduction in the mean SB, SGOT, SGPT, AP levels, PT and mean period required for total (symptomatic, clinical and biochemical) recovery. The decreased SA and SG levels were also increased extensively, when compared to the pre-treatment values, in all studies. There were no reported or observed significant adverse events in all trials and the on the whole drug compliance was excellent. Therefore, this metaanalysis concludes that, Liv.52 tablets and syrup are effective and also safe in the management of hepatitis.
Liv.52 regulates ethanol induced PPARgamma and TNF alpha expression in HepG2 cells.
Mol Cell Biochem. 2008 May 1.
Mitra SK, Varma SR, Godavarthi A, Nandakumar KS.
Liver is a major target of alcohol-induced damage by inducing inflammatory cytokines especially tumor necrosis factor alpha (TNFalpha). Activator of peroxisome proliferator activator receptor gamma (PPARgamma) is protective alongside alcohol-induced liver injury in animals. Liv.52, one of the major herbal hepatoprotective drugs, is shown to protect the liver from the toxicity and is considered to be an effective hepatoprotective agent. However, the signal pathway that involved in the Liv.52-induced hepatoprotection is not understood well specially in the case of cultured liver cells treated with ethanol. Hence, the study was aimed at determining whether the ethanol and Liv.52 could modulate PPARgamma and TNFalpha induction in human hepatoma cells, HepG2. The present study with the RT-PCR and confocal microscopy experiments showed that ethanol (100 mM) induced suppression of PPARgamma expression in HepG2 cells. The ethanol-induced PPARgamma suppression was so abrogated by Liv.52. Moreover, Liv.52 also induced upregulation of PPARgamma mRNA in liver cells as this compared to the untreated cells. Further, 100 mM ethanol has also induced TNFalpha gene expression in HepG2 cells and interestingly Liv.52 abolished ethanol-induced TNFalpha. The study also shows that Liv.52 alone downregulated the TNFalpha expression in HepG2 cells. Taken together, these findings suggest that Liv.52 is capable of attenuating ethanol-induced expression of TNFalpha and moreover abrogating ethanol-induced suppression of PPARgamma in liver cells. These results also indicate that Liv.52-induced PPARgamma expression and concomitant suppression of ethanol-induced elevation of TNFalpha in HepG2 cells suggest the immunomodulatory and the hepatoprotective nature of Liv.52.
A trial with Liv.52 in infective hepatitis
Vijaykumar, S. Karachi, M.B.,B.S., X-ray Unit, Talikoti, Karnataka, India.
heightened infective hepatitis is a common infectious disease due to a virus which spreads by the oral and faecal contamination. In this study there were 32 cases of infective hepatitis, modest to severe, from an endemic malarial area. All the patients had a history of repeated attacks of the malarial fever and had received so anti-malarial treatment with 4-Aminoquinoline as well as 8-Aminoquinoline. Patients had fever, loss of appetite, vomiting (some cases), yellowish discoloration of the sclera and affectionate enlarged liver with splenomegaly. Urine examination was done for existence of bile pigments and bile salts. Ten patients had unsympathetic jaundice and they received treatment with Liv.52 tablets, 2 t.i.d. and Injection B Complex, 2 ml I.M. daily, and tapering doses of steroids with the I.V. fluids whenever necessary for one and a half months. All patients were evaluate fortnightly. After one month all of them showed marked expansion. In mild to moderate cases urine examination showed absence of bile pigments and the bile salts. This study shows that Liv.52 tablets, 2 t.i.d. can be used successfully and safely in all types of jaundice.
Prevention of mercuric chloride induced histopathological changes in the small intestine of mice with Liv-52.
Johnson V, Rathore HS. Cell Biology Unit, School of Studies in Zoology, Vikram University, Ujjain, India.
Mercuric chloride was administered in drinking water to mice at 1 mM and 5 mM for 100 and 30 days respectively. Lower concentration caused mild pathological changes in the small intestine while higher concentration caused severe pathological changes. Pathological symptoms were less pronounced when Liv52 was administered along with 5 mM mercuric chloric and Hg-induced changes were totally absent when drug was used along with 1 mM HgCl2 solution. After Hg-exposure at both concentrations mice were allowed to recover naturally or with drug (Post-therapy). Again, use of drug appeared useful. At least under laboratory conditions this herbal drug seems to reduce Hg-induced pathological changes in small intestine of mice.
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